PMID-19167367[0] Subthalamic nucleus discharge patterns during movement in the normal monkey and Parkinsonian patient.
- Compared STN activity in normal monkeys and parkinsonian humans performing the same joystick target acquisition task.
- PD neurons were much burstier, and had lower variance in responses.
- Simultaneously recorded neurons in the human demonstrated consistent oscillatory synchronization at restricted frequency bands, whereas synchronized oscillatory neurons in the monkey were not restricted to distinct frequencies (this is possibly not meaningful).
- the net effect of PD may be a reduction in the physiological degrees of freedom of BG neurons with diminished information carrying capacity.
- PETHs look bad compared to our results.
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[0] Gale JT, Shields DC, Jain FA, Amirnovin R, Eskandar EN, Subthalamic nucleus discharge patterns during movement in the normal monkey and Parkinsonian patient.Brain Res 1260no Issue
15-23 (2009 Mar 13) |
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