PMID-10854347[0] The pathophysiology of essential tremor
- http://www.medscape.com/viewarticle/461397_7 (you need to register to read more than 1 page)
- Not on Neurology website :-(
- Elevated blood concentrations of harmane and harmine were noted in essential tremor cases compared with non-essential tremor controls [30]
- Suggest that this may be dietary or endogenous synthesis.
- 50% hereditary.
- Tremor is severe and debilitating; use of hands may become dangerous, eating difficult.
- Unilateral thaladectomy is recommend in some cases; targets VIM, as does DBS.
- Generally higher frequency than PD (resting) tremor.
- Tremor can be Postural, Kinetic or Isometric; first two associated with ET. (or lithium cerebellar damage)
____References____
[0] Deuschl G, Elble RJ, The pathophysiology of essential tremor.Neurology 54:11 Suppl 4, S14-20 (2000) |
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