m8ta
You are not authenticated, login.
text: sort by
tags: modified
type: chronology
[0] Shuler MG, Bear MF, Reward timing in the primary visual cortex.Science 311:5767, 1606-9 (2006 Mar 17)

[0] Bair W, Koch C, Temporal precision of spike trains in extrastriate cortex of the behaving macaque monkey.Neural Comput 8:6, 1185-202 (1996 Aug 15)[1] Shmiel T, Drori R, Shmiel O, Ben-Shaul Y, Nadasdy Z, Shemesh M, Teicher M, Abeles M, Neurons of the cerebral cortex exhibit precise interspike timing in correspondence to behavior.Proc Natl Acad Sci U S A 102:51, 18655-7 (2005 Dec 20)[2] Mainen ZF, Sejnowski TJ, Reliability of spike timing in neocortical neurons.Science 268:5216, 1503-6 (1995 Jun 9)

{677}
hide / / print
ref: Wiener-2008.08 tags: STN operant conditioning timing rats lesion DBS impulsivity date: 01-26-2012 17:29 gmt revision:3 [2] [1] [0] [head]

PMID-18562098[0] Accurate timing but increased impulsivity following excitotoxic lesions of the subthalamic nucleus.

  • Synopsis: Animals whose STNs were lesioned were able to maintain temporal control and response on a peak interval timing task, but they were unable to inhibit operant responses late into the trial. This suggests that STN may be used in impulse control / behavioral inhibition.

____References____

[0] Wiener M, Magaro CM, Matell MS, Accurate timing but increased impulsivity following excitotoxic lesions of the subthalamic nucleus.Neurosci Lett 440:2, 176-80 (2008 Aug 1)

{630}
hide / / print
ref: Shuler-2006.03 tags: reward V1 visual cortex timing reinforcement surprising date: 01-03-2012 02:33 gmt revision:4 [3] [2] [1] [0] [head]

PMID-16543459[0] Reward Timing in the Primary Visual Cortex

  • the responses of a substantial fraction of neurons in the primary visual cortex evolve from those that relate solely to the physical attributes of the stimuli to those that accurately predict the timing of reward.. wow!
  • rats. they put goggles on the rats to deliver full-fields retinal illumination for 400ms (isn't this cheating? full field?)
  • recorded from deep layers of V1
  • sensory processing does not seem to be reliable, stable, and reproducible...
  • rewarded only half of the trials, to see if the plasticity was a result of reward delivery or association of stimuli and reward.
  • after 5-7 sessions of training, neurons began to respond to the poststimulus reward time.
  • this was actually independent of reward delivery - only dependent on the time.
  • reward-related activity was only driven by the dominant eye.
  • individual neurons predict reward time quite accurately. (wha?)
  • responses continued even if the animal was no longer doing the task.
  • is this an artifact? of something else? what's going on? the suggest that it could be caused by subthreshold activity due to recurrent connections amplified by dopamine.

____References____

{325}
hide / / print
ref: Bair-1996.08 tags: precise spike timing cortex behavior Sejnowski date: 04-09-2007 00:57 gmt revision:0 [head]

PMID-8768391[0] Temporal precision of spike trains in extrastriate cortex of the behaving macaque monkey

  • This temporal modulation is stimulus dependent, being present for highly dynamic random motion but absent when the stimulus translates rigidly -- that is, the response is markedly reproducable and precise to a few milliseconds.

PMID-16339894[1] Neurons of the cerebral cortex exhibit precise interspike timing in correspondence to behavior.

  • in the cortex, spikes can be very precise.
  • this was a slice investigation.

PMID-7770778[2] Reliability of spike timing in neocortical neurons.

  • neocortex of rats
  • suggest low intrinsic noise level in spike generation, allowing accurate transformation of synaptic input into spike generation

____References____

{191}
hide / / print
ref: Kerr-2004.01 tags: UP_DOWN states striatum cortex spike timing date: 0-0-2007 0:0 revision:0 [head]

PMID-14749432 Action Potential Timing Determines Dendritic Calcium during Striatal Up-States

  • striatum has up/down states too!
  • only read the abstract.

{44}
hide / / print
ref: notes-0 tags: spike patterns neural response LGN spike_timing Sejnowski vision date: 0-0-2006 0:0 revision:0 [head]

http://www.jneurosci.org/cgi/reprint/24/12/2989.pdf

  • quote: " when a cortical neuron is repeatedly injected with the same fluctuating current stimulus, the timing of the spikes is highly precise from trial to trial and the spike pattern appears to be unique"
    • though: I'd imagine that somebody has characterized the actual transfer function of this.
  • mais: we conclude that the prestimulus history of a neuron may influence the precise timing of the spikes in repsonse to a stimulus over a wide range of time scales.
  • in vivo, it is hard to find patterns because neurons may jump between paterns & there is a large ammount of neuronal noise in there too. or there may be neural "attractors".
  • they observed long-term (seconds) firing patterns in cat LGN (interesting)