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{1202}
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ref: -0 tags: saccarose sugar sweet electrode implantation force germany date: 01-24-2013 21:46 gmt revision:0 [head]

PMID-22254391 Chronic intracortical implantation of saccharose-coated flexible shaft electrodes into the cortex of rats.

  • measured forces of about 6mN inserting the 75um diameter saccharose-coated electrode.
    • Individual wires were 40um in diameter.
  • Limited longitudinal histology or electrophysiology

{1190}
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ref: Biran-2005.09 tags: Tresco histology chronic implantation astrocytes microglia date: 01-04-2013 02:28 gmt revision:3 [2] [1] [0] [head]

PMID-16045910[0] Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays.

  • We observed persistent ED1 immunoreactivity around implanted silicon microelectrode arrays implanted in adult rat cortex that was accompanied by a significant reduction in nerve fiber density and nerve cell bodies in the tissue immediately surrounding the implanted silicon microelectrode arrays.
  • We found that explanted electrodes were covered with ED1/MAC-1 immunoreactive cells and that the cells released MCP-1 and TNF-a under serum-free conditions in vitro.
  • See also [1] and [2]
  • Electrodes: Michigan type, 5mm long, 200um wide tapering to 30um, 15um thick at the shank tapering to 2um.
    • Show that the chronic response is markedly different than acute stab wounds.
    • "Stab wounds resulted in comparatively minimal neurofilament loss at 2 weeks (A) and no apparent loss by 4 weeks".
    • "The number of neuronal bodies is reduced in the area adjacent to microelectrodes (B, D) but appears unaltered surrounding stab wound lesions (A, C; lesion site in center of each image)."
  • Includes details of immunostaining, which could be useful.

____References____

[0] Biran R, Martin DC, Tresco PA, Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays.Exp Neurol 195:1, 115-26 (2005 Sep)
[1] Szarowski DH, Andersen MD, Retterer S, Spence AJ, Isaacson M, Craighead HG, Turner JN, Shain W, Brain responses to micro-machined silicon devices.Brain Res 983:1-2, 23-35 (2003 Sep 5)
[2] Gilletti A, Muthuswamy J, Brain micromotion around implants in the rodent somatosensory cortex.J Neural Eng 3:3, 189-95 (2006 Sep)

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ref: -0 tags: Purdue magnetic bullet electrode implantation date: 01-04-2013 00:51 gmt revision:3 [2] [1] [0] [head]

PMID-19596378 Magnetic insertion system for flexible electrode implantation.

  • Probes constructed from a sharp magnetic tip attached to a flexible tether.
  • Cite Polikov et al 2005. {781}.
  • Re micromotion: (Gilletti and Muthuswamy, 2006 {1102}; Lee et al., 2004; Subbaroyan et al., 2005 {1103}).
  • 0.6 mm (600 um!) diameter steel bullet, 4mm long, on the end of 38 gauge magnet wire. Mass 7.2 +- 0.4 mg.
  • Peak current 520 A froman 800V, 900uF capacitor which produces a maximum force of 10 N on the electrode, driving it at 126.25 m/s.
  • Did manage to get neural data.
  • Experimental evidence suggests that macrophages have difficulty adhering to and spreading on polymer fibers ranging between 2.1 and 5.9 um in diameter. PMID-8902241 Bernatchez et al. 1996 and {746}.
  • Shot through the dura.
  • Also reference magnetic stereotaxis for use in manipulating magnetic 'seeds' through cancers for hyperthremic destruction.
  • See also their 2011 AES abstract

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ref: -0 tags: electrode implantation spring modeling muscles sewing date: 01-16-2012 17:30 gmt revision:0 [head]

PMID-21719340 Modelization of a self-opening peripheral neural interface: a feasibility study.

  • Electrode is self-opening, and they outline the math behind it. This could be useful!