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ref: -2020 tags: excitatory inhibitory balance E-I synapses date: 10-06-2021 17:50 gmt revision:1 [0] [head]

Whole-Neuron Synaptic Mapping Reveals Spatially Precise Excitatory/Inhibitory Balance Limiting Dendritic and Somatic Spiking

We mapped over 90,000 E and I synapses across twelve L2/3 PNs and uncovered structured organization of E and I synapses across dendritic domains as well as within individual dendritic segments. Despite significant domain-specific variation in the absolute density of E and I synapses, their ratio is strikingly balanced locally across dendritic segments. Computational modeling indicates that this spatially precise E/I balance dampens dendritic voltage fluctuations and strongly impacts neuronal firing output.

I think this would be tenuous, but they did do patch-clamp recording to back it up, but it's vitally interesting from a structural standpoint. Plus, this is a enjoyable, well-written paper :-)

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ref: -2018 tags: sparse representation auditory cortex excitatation inhibition balance date: 03-11-2019 20:47 gmt revision:1 [0] [head]

PMID-30307493 Sparse Representation in Awake Auditory Cortex: Cell-type Dependence, Synaptic Mechanisms, Developmental Emergence, and Modulation.

  • Sparse representation arises during development in an experience-dependent manner, accompanied by differential changes of excitatory input strength and a transition from unimodal to bimodal distribution of E/I ratios.