PMID-20613723 Regulation of parkinsonian motor behaviors by optogenetic control of basal ganglia circuitry
- Kravitz AV, Freeze BS, Parker PR, Kay K, Thwin MT, Deisseroth K, Kreitzer AC.
- Generated mouse lines with channelrhodopsin2, with Cre recombinase under control of regulatory elements for the dopamine D1 (direct) or D2 (indirect) receptor.
- optogenetic exitation of the indirect pathway elicited a parkinsonian state: increased freezing, bradykinesia and decreased locomotor initiations;
- Activation of the direct pathway decreased freezing and increased locomotion.
- Then: 6OHDA depletion of striatal dopamine neurons.
- Optogenetic activation of direct pathway (D1 Cre/loxp) neurons restored behavior to pre-lesion levels.
- Hence, this seems like a good target for therapy.
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