IEEE-1605268 (pdf) Evaluation of the Stability of Intracortical Microelectrode Arrays
- 35-50um IR electrodes, electrolytically sharpened at a 10 deg angle, with a 5um blunted tip.
- Electrodes coated in parylene, and exposed at the tip with an eximer laser. Surface area of tip ~500um^2.
- Sorted based on features (duration, pk-pk, ratio of + to -, ratio of + time to - time), followed by a demixing matrix (PCA?)
- Did experiments in 25 cats with some task (for another paper?); got recordings for up to 800 days. Seems consistent with our results.
- Neurons were stable (by their metrics) for up to 60 days.
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- sparse arrays showed stable recordings sooner than dense arrays, perhaps because they are larger and more qucikly become attached to the dura.
- Electrodes were always unstable for the first 2-3 months. Stability index is as high as 30-40 days.
- Average electrode yield was ~ 25%.
- no histology.
____References____
Xindong Liu and McCreery, D.B. and Bullara, L.A. and Agnew, W.F. Evaluation of the stability of intracortical microelectrode arrays Neural Systems and Rehabilitation Engineering, IEEE Transactions on 14 1 91 -100 (2006) |