PMID-10906696[0] Tissue response to single-polymer fibers of varying diameters: evaluation of fibrous encapsulation and macrophage density.
- Fibers smaller than show reduced immune response.
- Fibers implanted in the subcutaneous dorsum (below the skin in the back of rats).
- Polypropylene. (like rope).
- Wish the result extended to small beads & small electrodes. is tiny, but possible with insulated Au wires.
- Beads: try PMID-1913150 -- shows that the 600um - 50um beads ('microspheres') are well tolerated.
- Also {750}.
- Macrophage density in tissue with fiber diameters 2.1-5.9um comparable to that of unoperated contralateral control.
"
fiber diameter | capsule thickness |
2.1-5.9 | 0.6 |
6.5-10.6 | 11.7 |
11.1-15.8 | 20.3 |
16.7-26.7 | 25.5 |
____References____
[0] Sanders JE, Stiles CE, Hayes CL, Tissue response to single-polymer fibers of varying diameters: evaluation of fibrous encapsulation and macrophage density.J Biomed Mater Res 52:1, 231-7 (2000 Oct) |
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