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[0] Mehta MR, Cortico-hippocampal interaction during up-down states and memory consolidation.Nat Neurosci 10:1, 13-5 (2007 Jan)[1] Ji D, Wilson MA, Coordinated memory replay in the visual cortex and hippocampus during sleep.Nat Neurosci 10:1, 100-7 (2007 Jan)

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ref: Mehta-2007.01 tags: hippocampus visual cortex wilson replay sleep learning states date: 03-09-2009 18:53 gmt revision:1 [0] [head]

PMID-17189946[0] Cortico-hippocampal interaction during up-down states and memory consolidation.

  • (from the associated review) Good pictorial description of how the hippocampus may impinge order upon the cortex:
    • During sleep the cortex is spontaneously and randomly active. Hippocampal activity is similarly disorganized.
    • During waking, the mouse/rat moves about in the environment, activating a sequence of place cells. The weights of the associated place cells are modified to reflect this sequence.
    • When the rat falls back to sleep, the hippocampus is still not random, and replays a compressed copy of the day's events to the cortex, which can then (and with other help, eg. ACh), learn/consolidate it.
  • see [1].

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