http://www.clinicaltrials.gov/ct2/show/NCT00558766?cond=Parkinson+Disease&rank=4 Salient points:
- Neurons in the mesencephalon : "Their role in reward processing is thought to be dual: i) they show sustained activity with the expectation of a future reward and ii) a phasic response after reward."
- Synapse on interneurons and cortical cells (e.g. from the substantia nigra), where they produce primary inhibition.
- That's interesting .. why would reward cause inhibition?? what models suggest this?
- Our hypothesis has been that a dopamine reward-related signal would increase the evocable inhibition in primary motor cortex and our findings support this.
- Check the first exclusion criteria: Pre-menopausal status in women: Preliminary data in healthy, cycling women suggests that the variation in paired-pulse inhibition caused by the menstrual cycle may obscure the change in the response induced by the behavioral task. What? Why?
- Others have found the same effect: PMID-18371077
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