PMID-15249649 Involvement of the human subthalamic nucleus in movement preparation
- STN receives large afferent from SMA, so it should be involved in movement planning.
- the STN and nearby structures are active before self-paced movements in humans.
- normal patients show a negative EEG movement-related potential (MRP) starting 1-2 seconds before the onset of self-paced movements.
- STN also shows premovement negative MRP.
- REquire very sensitive methods to record this MRP -- it's on the order of 1 uv.
- the amplitude of the scalp MRP is reduced in parkinson's patients.
- impairment of movement preparation in PD may be related to deficits in the SMA and M1, e.g. underactivity.
- the MRP is normalized with the administration of levodopa.
- MPTP monkeys have increased activity in the STN
- examined the role of the STN in movement preparation and inhibition via MRP recorded from DBS electrodes in the STN + simultaneously recorded scalp electrodes.
- their procedure has the leads externalized during the first week after surgery.
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