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ref: Stensaas-1976.01 tags: histology implant electrodes immune response date: 01-25-2013 02:52 gmt revision:1 [0] [head]

PMID-782142[0] The reaction of the cerebral cortex to chronically implanted plastic needles.

  • Three different classes of result:
    • Type I is characterized by little or no gliosis and synapses within 1-5mu of the implant;
    • type II contains a pronounced zone of reactive astrocytes;
    • type III is typified by a zone of connective tissue near the implant surface
      • One implant can evince all 3 different types!
  • Already were thinking of neuroprosthetic devices.

____References____

[0] Stensaas SS, Stensaas LJ, The reaction of the cerebral cortex to chronically implanted plastic needles.Acta Neuropathol 35:3, 187-203 (1976)