PMID-15698656[0] A comparison of chronic multi-channel cortical implantation techniques: manual versus mechanical insertion.
- Over 60% of the animals implanted with the mechanical insertion device had driven activity at week 6
- whereas none of the animals with manually inserted arrays exhibited functional responses after 3 weeks.
- Roughly identical responses immediately following surgery.
- Could be that the manual inserter had horizontal movement / shear. (This is solveable with a stereotax).
- Other research showed little difference in tissue response at 10um/s or 100um/s PMID-21896383[1]
- Multi-wire electrodes.
- Mechanical insertion device was capable of rapidly inserting the electrode without visible compression of the brain.
- Response measured relative to auditory stimulus.
- Their insertion device looks like a pen.
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____References____
[0] Rennaker RL, Street S, Ruyle AM, Sloan AM, A comparison of chronic multi-channel cortical implantation techniques: manual versus mechanical insertion.J Neurosci Methods 142:2, 169-76 (2005 Mar 30) |
[1] Welkenhuysen M, Andrei A, Ameye L, Eberle W, Nuttin B, Effect of insertion speed on tissue response and insertion mechanics of a chronically implanted silicon-based neural probe.IEEE Trans Biomed Eng 58:11, 3250-9 (2011 Nov) |
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