PMID-16107540[0] Distinct basal ganglia territories are engaged in early and advanced motor sequence learning
- generally a broad, well-referenced study.
- they used a really high-field magnet (3T) during tapping-learning task over the course of a month.
- STN was activated early in motor learning, but not afterward, specifically the sequence learning
- during the course of learning (an as the task became progressively more automatic) associative striatal activation shifted to motor activity.
- STN could act by inhibiting competing motor outputs, thus building a temporally ordered sequence of movements.
- SN was active throughout the course of the experiment.
- during the 'fast learning' stage, there was transient activation of the ACC
- also during the beginning portion of motor learning lobules V and VI of the cerebellum were activated.
- rostral premotor and prefrontal cortical areas are connected to the associative territory of the striatum, which projects back to the frontal cortex the VA/VL nuclei of the thalamus.
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[0] Lehéricy S, Benali H, Van de Moortele PF, Pélégrini-Issac M, Waechter T, Ugurbil K, Doyon J, Distinct basal ganglia territories are engaged in early and advanced motor sequence learning.Proc Natl Acad Sci U S A 102:35, 12566-71 (2005 Aug 30) |
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