PMID-21298109[0] Implant size and fixation mode strongly influence tissue reactions in the CNS.
- Overview: tethering and size both increase immune response, and causes continued GFAP activity.
- An untethered 50um electrode exhibited very weak inflammatory response after 12 weeks.
- Suggesting that a small electrode can move with the brain.
- Tethering in their context means affixed rigidly to the bone.
- Small-diameter, untethered implants cause the smallest tissue reactions.
- Likely that this scales.
- Stice et al 2007 {1111} -- GFAP expression was significantly smaller for 12 um diameter implants than 25um implants @ 4 weeks.
- They used 50um and 200um stainless steel implants.
- implants glued to micromanipulator using gelatine
- 24 rats.
- Much more GFAP and ED1 actviity in tethered implants; NEuN neural density about the same.
- 50um implant had a higher NeuN + count.
- Regarding implantation: not sure. Have to find a reference for stab wounds (where the inserter is retracted).
____References____
[0] Thelin J, Jörntell H, Psouni E, Garwicz M, Schouenborg J, Danielsen N, Linsmeier CE, Implant size and fixation mode strongly influence tissue reactions in the CNS.PLoS One 6:1, e16267 (2011 Jan 26) |
|