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ref: -2016 tags: somatostatin interneurons review date: 02-11-2018 18:08 gmt revision:0 [head]

PMID-27225074 Somatostatin-expressing neurons in cortical networks.

  • Urban-Ciecko J1, Barth AL1.
  • High (~ 10hz) tonic (constitutive) firing rate. All GABA.
  • Somatostatin, a neuropeptide, is of ill-defined role. Unknown when it is released.
  • SST interneurons receive diffuse input from cortical pyramidal cells, but each synapse is of low strength.
  • SST intererneurons are frequently electrically connected through gap junctions, but almost never through electrical synapses. The resulting network can extend for hundreds of microns, and has been shown to cause synchronized firing when cells are active.
  • Common anesthetics (isoflurane, urethane) profoundly silence the SSTs.
  • Wide diversity of axonal and dendritic branching patterns, targeting both apical (20%) and distal pyramidal cell dendrites.
  • SST neuron activity is reduced in Dravet syndrome.
  • SST neurons have also been implicated in schizophrenia; affected individuals show decreased SST mRNA and mislocalization of SST interneurons.