PMID-17978020[0] The Upshot of Up States in the Neocortex: From Slow Oscillations to Memory Formation
- slow waves are caused by spreading synchronous up/down depolarizations in the neocortex during SWS
- the slow waves are thought to be generated intrinsically (?)
- cortex is insensitive in up states, but highly sensitive to thalamic stimulation in down states? humm, need to see the data for that - from slices.
- quote: "According to some theories of memory consolidation (Marr, 1971Go; Buzsáki, 1989Go; Squire, 1992Go; McClelland et al., 1995Go), memories are thought to be minted rapidly in the hippocampus during behavior and transferred to the neocortex during slow-wave sleep for long-term storage."
- there is other stuff about 50-150 Hz activation in the hippocampus leading to neocortical activation, and that this is associated with transfer from labile hippocampus to long-term neocortex.
- the review gives an impression of not being as concrete as, say, Buzsaki.
____References____
[0] Hoffman KL, Battaglia FP, Harris K, MacLean JN, Marshall L, Mehta MR, The upshot of up states in the neocortex: from slow oscillations to memory formation.J Neurosci 27:44, 11838-41 (2007 Oct 31) |
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