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{1400}
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ref: -0 tags: robinson pasquali carbon nanotube fiber fluidic injection dextran neural electrode date: 12-28-2017 04:20 gmt revision:0 [head]

PMID-29220192 Fluidic Microactuation of Flexible Electrodes for Neural Recording.

  • Use viscous dextran solution + PDMS channel system
  • Durotomy (of course)
  • Parylene-C insulated carbon fiber electrodes, cut with FIB or razor blade
  • Used silver ink to electrically / mechanically attach for recordings.
  • Tested in hydra, rat brain slice (reticular formation of thalamus), and in-vivo rat.
  • Electrodes, at 12um diameter, E=120GPa, are approximately 127x stiffer than one 4x20um PI (E=9GPa) probe. Less damage though.

{1246}
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ref: -0 tags: parylene microchannel micromolding glass transition temperature microfluidics date: 06-28-2013 17:34 gmt revision:3 [2] [1] [0] [head]

Parylene micromolding, a rapid low-cost fabrication method for parylene microchannel

  • doi:10.1016/j.snb.2003.09.038
  • Hong-Seok Noha∗ , Yong Huangb, Peter J. Hesketha Clemson
  • Parylene properties:
    • Glass transition temperature <90C; c.f. {1247}
    • Melting point 290C
    • Oxidation in air at 120C
    • Thermal bonding here at 200C in a vacuum oven @ 24MPa.

{1178}
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ref: -0 tags: parylene flexible neural recording drug delivery microfluidics 2012 inserter needle release date: 01-02-2013 22:41 gmt revision:1 [0] [head]

PMID-23160191 Novel flexible Parylene neural probe with 3D sheath structure for enhancing tissue integration

  • They seem to think that drugs are critical for success: "These features will enhance tissue integration and improve recording quality towards realizing reliable chronic neural interfaces."
  • Similar to Kennedy: "The sheath structure allows for ingrowth of neural processes leading to improved tissue/probe integration post implantation." 8 electrodes, 4 on the cone interior, 4 on the exterior.
    • opening is 50um at tip, 300 um at base.
  • Used a PEEK-stiffened parylene ZIF connection.
  • Only tested in agarose, but it did properly release from the inserter needle.
  • I wonder if we could use a similar technique..
  • "Lab on a chip" journal (Royal society of Chemistry). nice.

{366}
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ref: Pearce-2004.01 tags: neural recording microfluidics in-vitro MEA date: 01-03-2012 06:53 gmt revision:4 [3] [2] [1] [0] [head]

PMID-17271187[0] Dynamic control of extracellular environment in in vitro neural recording systems.

  • they show how to create microfluidic channels on top of in-vitro microfluidic arrays.
  • used dorsal root ganglion cells.
  • key aspect:
    • make a thin cavity/space between two polycarbonate panes.
    • fill the cavity with liquid-phase isobornyl acrylate
    • cover the panes with a high-resolution mask
    • upon exposure to UV light the isobornyl polymerizes.
    • did this on top of a MEA-60
  • looks like they can very accurately deliver pulses and streams of fluid.

____References____

[0] Pearce T, Oakes S, Pope R, Williams J, Dynamic control of extracellular environment in in vitro neural recording systems.Conf Proc IEEE Eng Med Biol Soc 6no Issue 4045-8 (2004)