PMID-17046697 Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction.
- used rats where they could rapidly switch between dopamine depletion (0.2%) and overexpression (500%)
- most cortical and striatal neurons ( approximately 70%) changed firing rate during the transition between dopamine-related hyperkinesia and akinesia,
- buuut the overall cortical firing rate remained unchanged
- repeated dopamine depletion is accompanied by the loss of glutamergic synapses in striatopallidal neurons (Day et al 2006) PMID-16415865 (Kaneda et al 2005). PMID-16367790
- with Marc Caron
- Dopamine is believed to modulate positively the direct striatal pathway that contains predominantly D1-type receptors and disinhibits cortical neurons to modulate negatively the indirect pathway that predominantly contains D2-type receptors and increased crotical inhibition (Albin et al 1989 {1050}, Filion and Tremblay 1991; Gerfen 1992, Parr-Brownlie and Hyland, 2005).
- According to the classical view (Albin et al 1989), lack of DA release should lead to inhibition of cortical activity and an inability to produce movement, while an excess of Dopamine should lead to increased cortical activity and hyperactivity (Gerfen, 1992).
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