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{1395}
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ref: -0 tags: Courtine e-dura PDMS silicone gold platinum composite stretch locomotion restoration rats date: 12-22-2017 01:59 gmt revision:0 [head]

PMID-25574019 Biomaterials. Electronic dura mater for long-term multimodal neural interfaces.

  • Fabrication:
    • 120um total PDMS thickness, made through soft lithography, covalent (O2 plasma) bonding between layers
    • 35nm of Au (thin!) deposited through a stencil mask.
    • 300um Pt-PDMS composite for electrode sites, deposited via screenprinting
  • 100 x 200um cross section drug delivery channel.
  • Compared vs. stiff 25um thick PI film electrode.
    • stiff implants showed motor impairments 1-2 weeks after implantation.
  • Showed remarkable recovery of supported locomotion with stimulation and drug infusion (to be followed by monkeys).

{1394}
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ref: -0 tags: Courtine PDMS soft biomaterials spinal cord e-dura date: 12-22-2017 01:29 gmt revision:0 [head]

Materials and technologies for soft implantable neuroprostheses

  • Quote: In humans, both the spinal cord and its meningeal protective membranes can experience as much as 10–20% tensile strain and
displacement (relative to the spinal canal) during normal postural movements. This motion corresponds to displacements on the order of centimetres17. The deformations relative to the spinal cord in animal models, such as rodents or non-human primates, are likely to be even larger.

{1257}
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ref: -0 tags: Anna Roe optogenetics artificial dura monkeys intrinisic imaging date: 09-30-2013 19:08 gmt revision:3 [2] [1] [0] [head]

PMID-23761700 Optogenetics through windows on the brain in nonhuman primates

  • technique paper.
  • placed over the visual cortex.
  • Injected virus through the artificial dura -- micropipette, not CVD.
  • Strong expression:
  • See also: PMID-19409264 (Boyden, 2009)

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ref: Rasch-2009.04 tags: REM learning procedural memory sleep spindles date: 03-23-2009 18:32 gmt revision:3 [2] [1] [0] [head]

PMID-18836440[0] Pharmacological REM sleep suppression paradoxically improves rather than impairs skill memory

  • surpressed REM sleep with SSRIs or norepinephrine reuptake inhibitor
    • yet tested the subjects after a long wash-out: 32 hours, including 2 nights sleep.
  • did not impair word-pair recognition, and improved finger tapping accuracy.
  • sleep spindles are a feature of non-REM sleep.
  • REM sleep is characterized by an abscence of serotonin and norepinephrine; SSRIs and SNRIs increase the levels of these two neurotransmitters, respectively, at the synaptic cleft.
  • clinical studies of depressed patients show no impairment of skill performance during long-term treatment with these drugs, despite marked REM supression
  • did mirror-tracing and finger-tapping tasks.
  • SSRI supressed REM sleep; SNRI almost completely removed REM.
  • treatment increased accuracy of finger tapping task! esp. for the SNRI.
    • increase in accuracy was positively correlated to the change in spindle density.
  • For the mirror task, there were notable improvements after sleep, but no significant difference between placebo, SSRI, and SNRI groups.
  • paired-word retention task has been shown dependent on SWS; it was not affected by pharmacology.
  • They suggest that perhaps SSRI /SNRI supressed simply the typical measures of REM sleep, and that other factors critical for the associated consolidation were unaffected (e.g. high cholinergic activity).
  • result is consistent with [1]

____References____

[0] Rasch B, Pommer J, Diekelmann S, Born J, Pharmacological REM sleep suppression paradoxically improves rather than impairs skill memory.Nat Neurosci no Volume no Issue no Pages (2008 Oct 5)
[1] Tamaki M, Matsuoka T, Nittono H, Hori T, Fast sleep spindle (13-15 hz) activity correlates with sleep-dependent improvement in visuomotor performance.Sleep 31:2, 204-11 (2008 Feb 1)