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[0] Rasch B, Gais S, Born J, Impaired Off-Line Consolidation of Motor Memories After Combined Blockade of Cholinergic Receptors During REM Sleep-Rich Sleep.Neuropsychopharmacology no Volume no Issue no Pages (2009 Feb 4)

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ref: -2006 tags: Mark Bear reward visual cortex cholinergic date: 03-06-2019 04:54 gmt revision:1 [0] [head]

PMID-16543459 Reward timing in the primary visual cortex

  • Used 192-IgG-Saporin (saporin immunotoxin)to selectively lesion cholinergic fibers locally in V1 following a visual stimulus -> licking reward delay behavior.
  • Visual stimulus is full-field light, delivered to either the left or right eye.
    • This is scarcely a challenging task; perhaps they or others have followed up?
  • These examples illustrate that both cue 1-dominant and cue 2-dominant neurons recorded from intact animals express NRTs that appropriately reflect the new policy. Conversely, although cue 1- and cue 2-dominant neurons recorded from 192-IgG-saporin-infused animals are capable of displaying all forms of reward timing activity, ‘’’they do not update their NRTs but rather persist in reporting the now outdated policy.’’’
    • NRT = neural reaction time.
  • This needs to be controlled with recordings from other cortical areas.
  • Acquisition of reward based response is simultaneously interesting and boring -- what about the normal, discriminative and perceptual function of the cortex?
  • See also follow-up work PMID-23439124 A cholinergic mechanism for reward timing within primary visual cortex.

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ref: Rasch-2009.06 tags: sleep cholinergic acetylcholine REM motor consolidation date: 02-18-2009 17:27 gmt revision:0 [head]

PMID-19194375[0] "Impaired Off-Line Consolidation of Motor Memories After Combined Blockade of Cholinergic Receptors During REM Sleep-Rich Sleep."

  • In REM sleep there is high, almost to wake-like, levels of ACh activity (in the cortex? they don't say).
  • Trained subjects on a motor task after a 3-hour period of slow wave sleep.
  • Then administered ACh (muscarinic + nicotinic) blockers or placebo
  • Subjects with blocked ACh reception showed less motor consolidation. So, ACh is needed! (This is consistent with Ach being an attentional / selective signal for activating the cortex).

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