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{1393}
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ref: -2001 tags: polyimide Kipke bioactive flexible electrode arrays date: 12-22-2017 01:16 gmt revision:2 [1] [0] [head]

PMID-11327505 Flexible polyimide-based intracortical electrode arrays with bioactive capability.

  • Appears to be the first or one of the first use of thin-film polyimide for intracortical recording; will have to cite.
  • Fab protocol: 500nm release thermal oxide, photo-paternable PI, Cr-Au metalization, O2 plasma de-scum for adhesion (ish?), <20um total thickness.
  • Conductive epoxy attachment to connector.

{1220}
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ref: -0 tags: histology review electrode response bioactive coatings date: 01-28-2013 20:16 gmt revision:0 [head]

PMID-20577634 Biocompatibility of intracortical microelectrodes: current status and future prospects.

  • ... but the most widely used method to enhance biocompatibility is the chemical modification of neural probe surfaces with anti-inflammatory compounds, adhesion proteins, or bioactive molecules (Heiduschka and Thanos, 1998; He et al., 2006; Ludwig et al., 2006; Moxon et al., 2007; Rennaker et al., 2007; Seymour and Kipke, 2007; Zhong and Bellamkonda, 2007; Leung et al., 2008; Williams, 2008; Grill et al., 2009)
    • Have any of these achieved success?
    • Many other polymers are basically biocompatible, provided they still insulate after equilibriating with the surrounding vapor pressure.
    • Personally I don't think biocoatings wil lmatter much if there is persistent shear at the interface.
  • Does make sense to have the electrode surface attractive to neurons (Kennedy..). For a later date.

{1201}
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ref: Kato-2006.01 tags: bioactive neural probes flexible parylene japan Kato microspheres date: 01-28-2013 03:57 gmt revision:1 [0] [head]

PMID-17946847[0] Preliminary study of multichannel flexible neural probes coated with hybrid biodegradable polymer.

  • Conference proceedings. a little light.
  • :-)
  • probes made of parylene-C

____References____

[0] Kato Y, Saito I, Hoshino T, Suzuki T, Mabuchi K, Preliminary study of multichannel flexible neural probes coated with hybrid biodegradable polymer.Conf Proc IEEE Eng Med Biol Soc 1no Issue 660-3 (2006)