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ref: -0 tags: 3D SHOT Alan Hillel Waller 2p photon holography date: 05-31-2019 22:19 gmt revision:4 [3] [2] [1] [0] [head]

PMID-29089483 Three-dimensional scanless holographic optogenetics with temporal focusing (3D-SHOT).

  • P├ęgard NC1,2, Mardinly AR1, Oldenburg IA1, Sridharan S1, Waller L2, Adesnik H3,4
  • Combines computer-generated holography and temporal focusing for single-shot (no scanning) two-photon photo-activation of opsins.
  • The beam intensity profile determines the dimensions of the custom temporal focusing pattern (CTFP), while phase, a previously unused degree of freedom, is engineered to make 3D holograph and temporal focusing compatible.
  • "To ensure good diffraction efficiency of all spectral components by the SLM, we used a lens Lc to apply a small spherical phase pattern. The focal length was adjusted so that each spectral component of the pulse spans across the short axis of the SLM in the Fourier domain".
    • That is, they spatially and temporally defocus the pulse to better fill the SLM. The short axis of the SLM in this case is Y, per supplementary figure 2.
  • The image of the diffraction grating determines the plane of temporal focusing (with lenses L1 and L2); there is a secondary geometric focus due to Lc behind the temporal plane, which serves as an aberration.
  • The diffraction grating causes the temporal pattern to scan to produce a semi-spherical stimulated area ('disc').
  • Rather than creating a custom 3D holographic shape for each neuron, the SLM is after the diffraction grating -- it imposes phase and space modulation to the CTFP, effectively convolving it with a holograph of a cloud of points & hence replicating at each point.

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ref: -2018 tags: sparse representation auditory cortex excitatation inhibition balance date: 03-11-2019 20:47 gmt revision:1 [0] [head]

PMID-30307493 Sparse Representation in Awake Auditory Cortex: Cell-type Dependence, Synaptic Mechanisms, Developmental Emergence, and Modulation.

  • Sparse representation arises during development in an experience-dependent manner, accompanied by differential changes of excitatory input strength and a transition from unimodal to bimodal distribution of E/I ratios.

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ref: -0 tags: spectroscopy frequency domain PMT avalanche diode laser Tufts date: 02-25-2014 19:02 gmt revision:0 [head]

Frequency-domain techniques for tissue spectroscopy and imaging

  • 52 pages, book chapter
  • Good detail on bandwidth, tissue absorption, various technologies.

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ref: bookmarks-0 tags: Alan Rudolph DARPA Miguel Nicolelis date: 03-10-2009 21:19 gmt revision:1 [0] [head]

Defense Advanced Research Projects Agency's Alan Rudolph:

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ref: bookmark-0 tags: postmodernism pseudoscience Alan Sokal date: 04-23-2007 03:47 gmt revision:0 [head]

http://www.physics.nyu.edu/faculty/sokal/pseudoscience_rev.pdf

  • idea: postmodernism attacks science by claiming that all observations are inherently subjective andn unsupported by evidence; pseudoscience attacks science by claiming subjective, unsupported assertions to be supported by the method andn courpus of scientific thought. One robs science of credibility, the other attempts to profit from scientific credibility due to its success in predicting physical phenomena.
    • Usually, knowledge of the field in question is enough to highlight pseudoscience.. and postmodernism (by his definition) can be spotted by its claims/lack thereof.
  • claims Judeanism & Christianity contain sections of pseudoscience
  • (pope) John Paul II is a pseudoscientist?