PMID-7814435 Fate and biocompatibility of three types of microspheres implanted into the brain.
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- microspheres ( ) appear to be engulfed or surrounded by histocytic cells.
- poly(e-caprolactone), which is supposed to be biodegradable, did not dissolve in the brain. The polymer is hydrophobic.
- 20um spheres could be engulfed by macrophages; their microspheres were too large, and were encapsulated in a thin coallagen layer and astrocytic process.
- no scale bars - annoying - but we can estimate the size of the coating to be about the same size as the beads themselves.
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