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[0] Fetz EE, Operant conditioning of cortical unit activity.Science 163:870, 955-8 (1969 Feb 28)[1] Fetz EE, Finocchio DV, Operant conditioning of specific patterns of neural and muscular activity.Science 174:7, 431-5 (1971 Oct 22)[2] Fetz EE, Finocchio DV, Operant conditioning of isolated activity in specific muscles and precentral cells.Brain Res 40:1, 19-23 (1972 May 12)

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ref: Fetz-1969.02 tags: BMI original Fetz operant conditioning date: 01-07-2012 19:04 gmt revision:7 [6] [5] [4] [3] [2] [1] [head]

PMID-4974291[0] Operant conditioning of cortical unit activity

  • (Abstract) The activity of single neurons in precentral cortex of unanesthetized monkeys (Macaca mulatta) was conditioned by reinforcing high rates of neuronal discharge with delivery of a food pellet. Auditory or visual feedback of unit firing rates was usually provided in addition to food reinforcement. After several training sessions, monkeys could increase the activity of newly isolated cells by 50 to 500 percent above rates before reinforcement.
  • Used 'classical' single unit recording.
  • Trepination 5mm circle over hand area.
  • feedback: click for each AP.
  • reinforced on neuron per day.
  • trained neural activity often bursts, usually involved movement such as flexion of the lebow or rotation of the wrist.
  • controlled for sensory positive-feedback loop by performing extinction trials & looking for PETH response to click.
  • I gotta get one of these pellet feeders. monkeys will likely be more motivated, especially if I titrate how frequently they get the food.
  • images/303_1.pdf

PMID-5000088[1] Operant conditioning of specific patterns of neural and muscular activity.

In awake monkeys we recorded activity of single "motor" cortex cells, four contralateral arm muscles, and elbow position, while operantly reinforcing several patterns of motor activity. With the monkey's arm held semiprone in a cast hinged at the elbow, we reinforced active elbow movements and tested cell responses to passive elbow movements. With the cast immobilized we reinforced isometric contraction of each of the four muscles in isolation, and bursts of cortical cell activity with and without simultaneous suppression of muscle activity. Correlations between a precentral cell and specific arm muscles consistently appeared under several behavioral conditions, but could be dissociated by reinforcing cell activity and muscle suppression.

PMID-4624487[2] Operant conditioning of isolated activity in specific muscles and precentral cells

Recorded precentral units in monkeys, trained to contract 4 arm muscles in isolation, under various conditions: passive movements and cutaneous stimulation, active movements and isometric contractions. Some Ss were also reinforced for activity of cortical cells, with no contingency in muscle activity and with simultaneous suppression of all muscular activity. It is concluded that temporal correlations between activity of precentral cells and some other component of the motor response, e.g., muscle activity, force, or position, may depend as strongly on the specific response pattern which is reinforced as on any underlying physiological connection.

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