PMID-16928796[0] Fast modulation of prefrontal cortex activity by basal forebrain noncholinergic neuronal ensembles
in the author's own words:
- in the intro sections, you can find the summary background info you need, both anatomical and functional. Despite the fact that most people think of this as solely the cholinergic projection system, my data is pointing to a very important role for the non-ACh projection system (most likely GABAergic!) in fast cortical modulation and ATTENTION. The relevant thing for you here is that, when people stimulated nucleus basalis and claimed the effect to be cholinergic, I believe most stimulation protocols (short bursts) are in fact mimicking the natural activity pattern of non-ACh projection system, and therefore should be re-interpreted with caution.
- the intro, as promised, is concise, relevant, and has a lot of references.
- key hypothesis is that the BF has GABA projections onto GABAergic interneurons in the PFC
- typically, people focus on ACh projections.. perhaps as a matter of tradition?
- PFC is reciprocally connected to the BF
- secondary thing to test was the difference in behavior of the basal-forebrain tonic neurons (BFTN) between sleep and wake states.
____References____
[0] Lin SC, Gervasoni D, Nicolelis MA, Fast modulation of prefrontal cortex activity by basal forebrain noncholinergic neuronal ensembles.J Neurophysiol 96:6, 3209-19 (2006 Dec) |
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