PMID-9464684[0] Physiological aspects of information processing in the basal ganglia of normal and parkinsonian primates.
- The firing of neurons in the globus pallidus of normal monkeys is almost always uncorrelated.
- after MPTP treatment, the firing patterns of GP became correlated and oscillatory (see the figures!!)
- dopamine must support normal segregation of the informational channels in the basal ganglia, and breakdown of this causes the pathology of PD.
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- has a decent diagram of the basal ganglia-thalamo-cortical circuits.
- two different hypotheses of BG function: segregated and convergent. data support the former.
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____References____
[0] Bergman H, Feingold A, Nini A, Raz A, Slovin H, Abeles M, Vaadia E, Physiological aspects of information processing in the basal ganglia of normal and parkinsonian primates.Trends Neurosci 21:1, 32-8 (1998 Jan) |
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