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ref: -2006 tags: Mark Bear reward visual cortex cholinergic date: 03-06-2019 04:54 gmt revision:1 [0] [head]

PMID-16543459 Reward timing in the primary visual cortex

  • Used 192-IgG-Saporin (saporin immunotoxin)to selectively lesion cholinergic fibers locally in V1 following a visual stimulus -> licking reward delay behavior.
  • Visual stimulus is full-field light, delivered to either the left or right eye.
    • This is scarcely a challenging task; perhaps they or others have followed up?
  • These examples illustrate that both cue 1-dominant and cue 2-dominant neurons recorded from intact animals express NRTs that appropriately reflect the new policy. Conversely, although cue 1- and cue 2-dominant neurons recorded from 192-IgG-saporin-infused animals are capable of displaying all forms of reward timing activity, ‘’’they do not update their NRTs but rather persist in reporting the now outdated policy.’’’
    • NRT = neural reaction time.
  • This needs to be controlled with recordings from other cortical areas.
  • Acquisition of reward based response is simultaneously interesting and boring -- what about the normal, discriminative and perceptual function of the cortex?
  • See also follow-up work PMID-23439124 A cholinergic mechanism for reward timing within primary visual cortex.