PMID-7983515[0] The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism
- idea: record from STN and GPi before and after MPTP treatment in green monkeys.
- recorded 4-8hz periodic activity (via autocorrelograms) in significantly more neurons from the MPTP treated animals in both the STN and GPi.
- mean firing rate was increased in STN,
- tremor-correlated cells found in both.
- burst activity higher in both, too.
- modulations in firing rate due to the application of flexion and extension torque pulses were higher in MPTP animals (duration and amplitude), in both areas.
- spikes were longer in MPTP
- no tyrosene hydroxylase activity in the PD mks.
- PD tremor only frequently occurs in green mks following MPTP
____References____
[0] Bergman H, Wichmann T, Karmon B, DeLong MR, The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism.J Neurophysiol 72:2, 507-20 (1994 Aug) |
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