{1163} revision 4 modified: 02-23-2017 22:03 gmt

PMID-8263001[0] Biocompatibility of silicon-based electrode arrays implanted in feline cortical tissue.

  • Tried two different times:
    • one day before euthanasia
    • 6 month implant.
  • Tried three different implants:
    • Uncoated silicon,
    • polymide coating
    • polymide coating with SiO2 adhesion layer / primer.
  • The last was the worst in terms of histopathological response.
  • Chronic implants showed relatively restrained immune response,
    • Gliosis was found around all tracks, 20-40um.
  • Encapsulation was less than 9um.
  • Edema and hemorrhage was minor but present on a subset of all implants.
  • Acute (24h) hemorrhage was more severe -- ~ 60%; edema ~ 20%.
  • Chronic histology revealed considerable macrophages w/ hemosiderin (a complex including ferritin)
  • See also [1]

____References____

[0] Schmidt S, Horch K, Normann R, Biocompatibility of silicon-based electrode arrays implanted in feline cortical tissue.J Biomed Mater Res 27:11, 1393-9 (1993 Nov)
[1] Jones KE, Campbell PK, Normann RA, A glass/silicon composite intracortical electrode array.Ann Biomed Eng 20:4, 423-37 (1992)