PMID-19660668[0] Functional neurosurgery for movement disorders: a historical perspective.
- Spinal cord LFS (30 Hz) has been used to treat intractible pain for decades.
- Based on experimental data obtained in MPTP-treated parkinsonian monkeys, the pedunculopontine nucleus has been used as a new target, and as suggested by the animal research results, its use indeed improves walking and stability when stimulation is performed at low frequency (25 Hz).
- But donesn't it induce feelings of well-being {1074}
- On freezing gait, which is non-dopamergic and not treated via STN DBS:
- Based on experimental data obtained in MPTP-treated parkinsonian monkeys, the pedunculopontine nucleus has been used as a new target, and as suggested by the animal research results, its use indeed improves walking and stability when stimulation is performed at low frequency (25 Hz)
- Many channel IPGS can target multiple structures with multiple frequencies; author thinks this is the future in terms of efficiency.
- Suggests brain-machine interfaces (?)
____References____
[0] Benabid AL, Chabardes S, Torres N, Piallat B, Krack P, Fraix V, Pollak P, Functional neurosurgery for movement disorders: a historical perspective.Prog Brain Res 175no Issue
379-91 (2009) |
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