PMID-18540149[0] Deep brain stimulation: how does it work?
- MPTP monkey research suggests that activation of output and the resultant change in pattern of neuronal activity that permeates throughout the basal ganglia motor circuit is the mechanism responsible for symptom improvement.
- Sensible network approach.
- If pathological plasticity mechanisms are responsible for the symptoms, perhaps we should look for similarly slow treatments?
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[0] Vitek JL, Deep brain stimulation: how does it work?Cleve Clin J Med 75 Suppl 2no Issue
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