PMID-19955287[0] Deep brain stimulation does not silence neurons in subthalamic nucleus in Parkinson's patients.
- word to that. not a functional lesion!
- Record SUA during DBS of the STN. good idea.
- Saw postpulse inhibition of 1-2 us 6 us after stim in 10 of the 14 analyzed
- might be pulse locked spikes .. but could not see them.
- predominant shift toward random firing.
- DBS parameters: 3-5V, 80-200 Hz, 90-200us pulses, 33 neurons 11 patients.
- DBS likely functions through white-matter activation to effect changes in neuronal activity throughout the BG - thalamus-cortex network.
- Looked at the spaces between stimulus artifact.
- nice figures.
- DBS did not change mean firing rate.
- Modeling studies suggest that DBS depolarizes myelinated fibers, without evoking or inhibiting discharges in local cell bodies (McIntyre et al 2004 ab PMID-14668299, Miocinovic et al 2006).
- From the former: Suprathreshold stimulation caused suppression of intrinsic firing in the soma, but generated efferent output at the stimulus frequency in the axon.
____References____
[0] Carlson JD, Cleary DR, Cetas JS, Heinricher MM, Burchiel KJ, Deep brain stimulation does not silence neurons in subthalamic nucleus in Parkinson's patients.J Neurophysiol 103:2, 962-7 (2010 Feb) |
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